Aaron Ciechanover Quotes

My interest in protein breakdown as a research problem began in l955 at about the time I joined the Biochemistry Department of Yale University. It was known that proteins break down intracellularly in the mature animal.

Proteins are constantly being degraded. Therefore, simultaneous production of proteins is required.

The development of methods to monitor protein dynamics in cells together with the discovery of specific and general lysosomal inhibitors have resulted in the identification of different classes of cellular proteins, long- and short-lived, and the findings of the differential effects of the inhibitors on these groups.

If a portion of a redwood is rotting, the redwood will send roots into its own form and draw nutrients out of itself as it falls apart. If we had redwood-like biology, if we got a touch of gangrene in our arm, then we could just, you know, extract the nutrients and the moisture out of it until it fell off.

If I'm not hungry and I'm busy, I am quite happy to skip a meal. It's informal intermittent fasting. I feel strongly that this is one of the strongest areas of longevity research.

You want to shock the body and not be constant. Intermittent fasting is an increasingly popular way: Skip breakfast, for example. Also lifting weights, losing your breath from exercise and alternating between hot and cold temperatures. We think these measures will only get us to 100 to 122 years old. That's our natural lifespan.

Lower caloric exposure and episodic fasting can extend the life span of all animals, the longer we spend in the catabolic state, the longer we live.

Few of us doubt that stealing is wrong, especially from the poor. But the accusation of 'cultural appropriation' is overwhelmingly being used as an objection to syncretism - the mixing of different thoughts, religions, cultures, and ethnicities that often ends up creating entirely new ones.

When you are adapting a book to a visual medium, you tend to leave a few things and add a few new ones.

I broke pretty much every rule of classic game design and tried to invent new ones.

Vanilla is anti-inflammatory and reduces free radicals.

Biology - DNA - is technology. It is coding. It is physical coding, but still code.

My mother wears glasses, and so do some of my friends. When they get new ones, the old glasses go in a drawer.

I take protein and amino acid supplements, but I honestly don't know if they do anything.

What a nightmare it would be if we individually had to criminalise every single abuse of every single commodity, market or financial product. There are thousands of these and new ones being invented every day. Such an approach would have disastrous implications for regulation and policy-making. Any slide towards it must be resisted.

Persuading employees to let go of old values and beliefs and adopt new ones can be challenging.

'Writing' is the wrong way to describe what happens to words in a movie. First, you put down words. Then you rehearse them with actors. Then you shoot the words. Then you edit them. You cut a lot of them, you fudge them, you make up new ones in voice-over. Then you cut it and throw it all away.

If you asked me what caused aging, I would say free radicals and molecules, which spontaneously shift and form and cause damage in all our cells and genes. The body usually repairs and replaces the damage in these genes. But as you get older, the aging clock turns down those defenses.

When we first signed to Loud, we had a 20-song demo. So all of those songs we wanted to put on the album. But we started making new ones, and through process of elimination, we wanted all the new ones. We didn't like the old ones no more.

You see, the patience of an audience is very short, particularly with a non-entity. You're an intruder, and you must make them laugh within three or four seconds. My poems fit the requirements, and I'm always thinking up new ones.

That there is as yet no drug for immortality - or, for that matter, for muscle growth in the infirm - does not mean that immortality is theoretically or even technically impossible.

'Orphee' is, for me, about changes: about moving to a new city, leaving behind an old life in Copenhagen, and building a new one in Berlin - about the death of old relationships and the birth of new ones.

People used to trade their guitars to get new ones; I never traded anything.

I just wanted to express myself and put out music of how I'm feeling - give back to my fans and gain new ones in the process.

I'm a protein enthusiast, as it forms the foundation of our nutrition.