Mitochondrial Dysfunction Quotes

Aging is basically the build-up of error: error at the genetic level, error at the cellular level. Cells normally repair themselves; that's why you heal when you get a cut. But even the mechanism of repair eventually falls apart.

Ageing is, simply and clearly, the accumulation of damage in the body. That's all that ageing is.

If you asked me what caused aging, I would say free radicals and molecules, which spontaneously shift and form and cause damage in all our cells and genes. The body usually repairs and replaces the damage in these genes. But as you get older, the aging clock turns down those defenses.

For healthy adult people, the really big thing we can foresee are ways of intervening in the ageing process, either by slowing or reversing it.

Because of the relationship between programmed cell death and human disease, the identification of the genes and proteins that function in the process of programmed cell death has provided new targets for possible intervention in a broad diversity of disorders.

Basically, the body does have a vast amount of inbuilt anti-ageing machinery; it's just not 100% comprehensive, so it allows a small number of different types of molecular and cellular damage to happen and accumulate.

My lab looks at the ability of stress hormones to kill brain cells, and basically we are trying to understand on a molecular level how a neuron dies after a stroke, a seizure, Alzheimer's, brain aging, and what these stress hormones do to make it worse.

Aging is not one process. It's many different things going on that cause us to age. I have a program that at least slows down each of these different processes.

My disease is a very rare form of muscular dystrophy, called disautonomic mitochondrial myopathy.

Studies in the emerging field of cellular bioenergetics, a branch of biochemistry concerned with how energy flows through living systems, suggest that molecules from orchids might be able to repair decaying mitochondria, the powerhouses of cells, in humans.