The key thing for an intellectually rigorous writer to come to grips with is the marginalization of literature by more technologically sophisticated and thus more visceral forms.
There was no audience for my books. The Indians didn't regard me as an Indian and North Americans couldn't conceive of me of a North American writer, not being white and brought up on wheat germ. My fiction got lost.
When my novels are packaged as exclusively for women, I'm not only cut off from a vital portion of my audience but clearly labelled as an author the literary establishment is free to dismiss.
Science fiction is the ugly stepchild of mainstream literature, and fantasy is the ugly stepchild of science fiction, and tie-in novels are the ugly stepchild of fantasy... and on and on and on.
We must protect the minority writers because they are the research workers of literature. They keep it alive. It has been fashionable of late to seek out and force such writers into more popular channels, to the detriment of both writer and an unprepared public.
There are many Latino writers as talented as I am, but because we are published through small presses, our books don't count. We are still the illegal aliens of the literary world.
It's still true that literary works by women, gays, and writers of color are often framed as specific, rather than universal, small rather than big, personal or particular rather than socially significant.
Between the two dream coasts, we're just called flyover country... If you aren't known as an amorphous Eastern Seaboard writer, you're dismissed as a regional author.
The true experimenters are there but no-one hears about them - the critical/review system tends to concentrate on the handful of 'major' writers and their promising successors; bookshops tend not to sell them; publishers don't promote them. It's the same fate as has befallen poetry.