It will be in the convergence of evolutionary biology, developmental biology and cancer biology that the answer to cancer will lie. Nor will this confluence be a one-way street.
Breast cancer isn't one disease - it's probably four or five different types, and without knowing what type a person has, you can't optimize treatment for them.
If you sequence a cancerous tumor, you should be able to tailor the therapy according to the root cause of the cancer. But it has taken so long to do the sequencing - which also requires time to prepare the samples and interpret the deluge of data that comes out - that the patients are already undergoing therapy by the process if over.
Although not yet routine, many cancer centers have the technology to sequence some or all of a patient's cancer genome. This can provide massive amounts of valuable information about your cancer, including whether you have genetic mutations and other abnormalities for which new drugs are available.
We are still working with an incomplete compass. The time is right to bring the full power of genomics to bear on the problem of cancer.
In the 1960s and '70s, there wasn't much evidence at all. We knew vaguely the causes of cancer, but methods like genomics were very new.
A breast cancer might turn out to have a close resemblance to a gastric cancer. And this kind of reorganization of cancer in terms of its internal genetic anatomy has really changed the way we treat and approach cancer in general.
If we had pursued what President Nixon declared in 1970 as the war on cancer, we would have cured many strains. I think Jack Kemp would be alive today. And that research has saved or prolonged many lives, including mine.
Every cancer looks different. Every cancer has similarities to other cancers. And we're trying to milk those differences and similarities to do a better job of predicting how things are going to work out and making new drugs.
I get really excited about specific therapies, personalized therapies. Like, let's say, taking a piece of someone's tumor and testing a bunch of treatments in a lab and being able to come up with the right therapy for that specific patient.
There are certain mutations you can find across cancers in different organs.
If you have lung cancer, the most important thing you can know is your genetic code.
If there's a seminal discovery in oncology in the last 20 years, it's that idea that cancer genes are often mutated versions of normal genes.
