William Randolph I was an American colonist, landowner, planter, merchant, and politician who played an important role in the history and government of the English colony of Virginia. He moved to Virginia sometime between 1669 and 1673, and married Mary Isham (ca. 1659 – 29 December 1735) a few years later. His descendants include many prominent individuals including Thomas Jefferson, John Marshall, Paschal Beverly Randolph, Robert E. Lee, Peyton Randolph, Edmund Randolph, John Randolph of Roanoke, George W. Randolph, and Edmund Ruffin. Genealogists have taken an interest in him for his progeny's many marital alliances, referring to him and Mary Isham as "the Adam and Eve of Virginia".