David Andrew Sinclair Quotes

Reducing caloric intake is the only proven method of extending life. If caloric intake is reduced to 20 percent below maintenance, you can extend your lifespan considerably.

If I'm not hungry and I'm busy, I am quite happy to skip a meal. It's informal intermittent fasting. I feel strongly that this is one of the strongest areas of longevity research.

Well, we all age, but I'd been taking herbal supplements for a long time.

Age is the single largest risk factor for an enormous number of diseases. So if you can essentially postpone aging, then you can have beneficial effects on a whole wide range of disease.

It is likely that we need more radiation to improve our longevity.

I'm the chief science officer of a foundation that works on the application of regenerative medicine to the problem of aging.

Immortality Device has been tested and researched by medical researchers all over the world from time to time. They email me and told me what they found. I post their results sometimes on my site.

I'm a strong believer in modern medicine. I think it has its use in society. I think it adds longevity to our life expectancy.

We have the means right now to live long enough to live forever. Existing knowledge can be aggressively applied to dramatically slow down aging processes so we can still be in vital health when the more radical life-extending therapies from biotechnology and nanotechnology become available. But most baby boomers won't make it because they are unaware of the accelerating aging process in their bodies and the opportunity to intervene.

[Anti-aging therapies will] never be perfect, but we'll be able to fix the things that 200-year-olds die of before we have any 200-year-olds, and the same for 300 and 400 and so on.

The good news is that even minimal activity can significantly extend life.

For women, eating just two handfuls of nuts a week may extend their lives as much as by jogging four hours a week.

Nutrition is an exciting, dynamic field - there are more than 10,000 articles published on human nutrition in medical journals every year.

On Monday and Thursday, I eat fewer than 500 calories a day; then I eat like a pig for the other five days. You 'surprise' the body: keep it guessing. I got the idea from a BBC documentary about this Indian man who seemed about 138 years old and said his secret was severe calorie restriction.

Reversal is something that has been demonstrated in a number of different animals in a number of different ways. I think that's going to translate into larger animals and humans. We won't know until we try. But we are trying 65 different genes in different combinations to see if we can reproduce the aging reversal that we've seen in small animals.

Telomerase Activation is the single most promising approach to reversing the effects of aging.

Resveratrol does not act primarily as an antioxidant. It is far more interesting and powerful than that. Resveratrol turns on our body's genetic defenses against diseases and aging itself.

We do some experiments in humans, some in mice, and there are some questions that can only be answered in nonhuman primates. It's true that you can't immediately say that those experiments will translate into human health, but nevertheless, it is obvious that having an understanding of human memory is going to be important for human health.

The way to make a worm live longer is probably quite different from making a human live longer.

Science is telling us that the reason people die is not because some god said so or because the laws of nature mandate it. People always die because of technical problems. And every technical problem has, in principle, a technical solution.

I don't think it is about stalling or curing: it's about reversing. Curing gives you the impression of immortality. Stalling gives you the impression that you'll be 85 forever, which is not great.

You want to shock the body and not be constant. Intermittent fasting is an increasingly popular way: Skip breakfast, for example. Also lifting weights, losing your breath from exercise and alternating between hot and cold temperatures. We think these measures will only get us to 100 to 122 years old. That's our natural lifespan.

Longevity is a big deal.

So what we're all hoping to do, us researchers, is to develop ways to not really just extend lifespan but to keep people healthier for longer. We may just have a greater impact than a single drug because these drugs could potentially treat one disease but prevent 20 others.

We see that mice that undergo caloric restriction show a lower telomere shortening rate than those fed with a normal diet. These mice therefore have longer telomeres as adults, as well as lower rates of chromosome anomalies.