There is nothing new to be discovered in physics now, All that remains is more and more precise measurement
Experimental science is a craft and an art, and part of the art is knowing when to end a fruitless experiment. There is a danger of becoming obsessed with a fruitless experiment even if it goes nowhere.
When an investigator has developed a formula which gives a complete representation of the phenomena within a certain range, he may be prone to satisfaction. Would it not be wiser if he should say 'Foiled again! I can find out no more about Nature along this line.'
When I was a student, the laws of physics were regarded as completely off limits. The job of the scientist, we were told, is to discover the laws and apply them, not inquire into their provenance.
As long as we do science, some things will always remain unexplained.
Scientific research sooner or later, but inevitably, encounters something ultimately given that it cannot trace back to something else of which it would appear as the regular or necessary derivative. Scientific progress consists in pushing further back this ultimately given.
It is because the method of physics does not satisfy the comprehension that we have to go on further.
I'm talking about science on the leading edge, where it's not clear which way things are going be cause we don't know, and I'm dealing with areas which we don't know about.
Basic research is to work at the very edge, the very border of, of knowledge, and move that border forward. You look and look for new secrets, and you don't know where it's going to lead you.
Part of the maturity of the sciences is an appreciation of which questions are best left to other disciplinary approaches.