Electron Microscopy Quotes

There are many cells you could look at forever in 3D.

You know, of course, the specimens are not alive. We have to fix them in a fixing liquid formaldehyde and then we have to do a rinsing and then we have to coat them in a thin layer of gold.

Crystallographers believed in X-ray results, which are of course very accurate. But the x-rays are limited, and electron microscopy filled the gap, and so the discovery of quasicrystals could have been discovered only by electron microscopy, and the community of crystallographers, for several years, was not willing to listen.

In the early 1950s, during the near avalanche of discoveries, rediscoveries, and redefinitions of subcellular components made possible by electron microscopy, those prospecting in this newly opened field were faced with the problem of what to do with their newly acquired wealth.

The brain is really hard to see. The whole thing is very large - the human brain is several pounds in weight - but the connections between brain cells, known as synapses, are really tiny. They're nanoscale in dimension. So if you want to see how the cells of the brain are connected in networks, you have to see those connections, those synapses.

On the recommendation of my professor in experimental physics, Paul Scherrer, I took an assistantship for electron microscopy at the Biophysics Laboratory at the University of Geneva in November 1953. This laboratory was animated by Eduard Kellenberger, and it had two prototype electron microscopes requiring much attention.

Our eyes only see the big dimensions, but beyond those there are others that escape detection because they are so small.

When, in 1949, I decided to join the little band of early explorers who had followed Albert Claude in his pioneering expeditions, electron microscopy was still in its infancy.

It would be great if you could cool the water and immobilise the molecules, though keeping the structure, because when it's frozen, when it's immobilised, you can have it in the electron microscope and the water will not evaporate because in the electron microscope, it must be under vacuum, and water at normal temperature evaporates.

Molecules A and B meet, marry, and beget the species. This takes place in one-millionth of a billionth of a second. This is a fundamental process in nature, and the world was looking for a way to be able to see the process. But many brilliant people said it couldn't be done.

The atom can't be seen, yet its existence can be proved. And it is simple to prove that it can't ever be seen. It has to be studied by indirect evidence - and the technical difficulty has been compared to asking a man who has never seen a piano to describe a piano from the sound it would make falling downstairs in the dark.

On April 8, 1982, I was alone in the electron microscope room when I discovered the Icosahedral Phase that opened the field of quasi-periodic crystals.