Allele Frequency Quotes

Neo-Darwinists ask us to believe in things not seen. We're not supposed to have an established religion in America, but we do, and it's called Darwinism .

If the mutation is partially transmitted to offspring, they too would have the advantage. And over time it might have come to dominate a small breeding group.

In general, the larger the breeding population, the slower the rate of evolution.

My experiments with single traits all lead to the same result: that from the seeds of hybrids, plants are obtained half of which in turn carry the hybrid trait (Aa), the other half, however, receive the parental traits A and a in equal amounts. Thus, on the average, among four plants two have the hybrid trait Aa, one the parental trait A, and the other the parental trait a. Therefore, 2Aa+ A +a or A + 2Aa + a is the empirical simple series for two differing traits.

While the Environmental Genome Project does not seek to assign allele frequencies, we are aware of the importance of accurate allele frequency estimates for future epidemiologic studies and the large sample sizes such estimates will require.

When I was working on my Ph.D., I developed a computer algorithm to look for rapid changes in populations' DNA. Our DNA changes constantly over generations, but if certain changes spread through a population more quickly than others, they are probably the beneficial results of natural selection. This is the protection we give ourselves to survive.

Quantitative work shows clearly that natural selection is a reality, and that, among other things, it selects Mendelian genes, which are known to be distributed at random through wild populations, and to follow the laws of chance in their distribution to offspring. In other words, they are an agency producing variation of the kind which Darwin postulated as the raw material on which selection acts.

The foundations of population genetics were laid chiefly by mathematical deduction from basic premises contained in the works of Mendel and Morgan and their followers. Haldane, Wright, and Fisher are the pioneers of population genetics whose main research equipment was paper and ink rather than microscopes, experimental fields, Drosophila bottles, or mouse cages. Theirs is theoretical biology at its best, and it has provided a guiding light for rigorous quantitative experimentation and observation.

The reduced variability of small populations is not always due to accidental gene loss, but sometimes to the fact that the entire population was started by a single pair or by a single fertilized female. These 'founders' of the population carried with them only a very small proportion of the variability of the parent population. This 'founder' principle sometimes explains even the uniformity of rather large populations, particularly if they are well isolated and near the borders of the range of the species.

It is important to consider whether the sample size selected by the Environmental Genome Project will provide sufficient power to discover most alleles relevant to gene-environment interactions.

As natural selection works solely by and for the good of each being, all corporeal and mental endowments will tend to progress toward perfection.

I think nobody would claim that random genetic drift is capable of producing adaptation, that is to say the illusion of design. Random genetic drift can't produce wings that are good at flying, or eyes that are good at seeing, or legs that are good at running. But random genetic drift probably is very important in driving evolution at the molecular genetic level.

In this generation, along with the dominating traits, the recessive ones also reappear, their individuality fully revealed, and they do so in the decisively expressed average proportion of 3:1, so that among each four plants of this generation three receive the dominating and one the recessive characteristic.