Michael Rosbash Quotes
It was always intriguing that flies had two peaks of activity, in the morning and evening, with a siesta during the day and not very much activity at night. There are several ways to explain that, but one possibility was that there were two clocks running - one governing the morning peak and one governing the evening peak.
"Two Clocks Tick in the Fruit Fly Brain." HHMI News, Howard Hughes Medical Institute, 13 Oct. 2004.
Michael Morris Rosbash is an American geneticist and chronobiologist. Rosbash is a professor and researcher at Brandeis University and investigator at the Howard Hughes Medical Institute. Rosbash's research group cloned the Drosophila period gene in 1984 and proposed the Transcription Translation Negative Feedback Loop for circadian clocks in 1990. In 1998, they discovered the cycle gene, clock gene, and cryptochrome photoreceptor in Drosophila through the use of forward genetics, by first identifying the phenotype of a mutant and then determining the genetics behind the mutation. Rosbash was elected to the National Academy of Sciences in 2003. Along with Michael W. Young and Jeffrey C. Hall, he was awarded the 2017 Nobel Prize in Physiology or Medicine "for their discoveries of molecular mechanisms controlling the circadian rhythm".