I began studying ribosomes as a postdoctoral fellow in Peter Moore's laboratory in 1978.
I wanted to reveal how genetic code is translated into protein. I knew a great application could be for antibiotics, since half of the useful ones target the ribosomes, but I didn't believe I could contribute to it. It was like the next Mount Everest to conquer. It was my dream to contribute something to humanity.
Ribosomes contain RNA, messenger RNA provides the information, transfer RNAs brings the amino acids; so the protein-making machinery is an RNA machinery, completely.
At the end of the 1970s, I was a young researcher at the Weizmann Institute with an ambitious plan to shed light on one of the major outstanding questions concerning living cells: the process of protein biosynthesis.
Many ribosomes act simultaneously along the mRNA, forming superstructures called polysomes.
Nucleic acids are the main information-carrying molecules of the cell, and, by directing the process of protein synthesis, they determine the inherited characteristics of every living thing. The two main classes of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
During the decade following the discovery of the double-helical structure of DNA, the problem of translation - namely, how genetic information is used to synthesize proteins - was a central topic in molecular biology.
In reality, a cell is a biological mini-me compared to the human body. A cell has every biological system that you have.
Moreover the incorporation requires the same components needed for protein synthesis, and is inhibited by the same inhibitors. Thus the system is most unlikely to be a complete artefact and is very probably closely related to genuine protein synthesis.
I started working on ribosomes when I was a post doc, in 1978, when it would have been impossible, really, to solve it. But, it was just a fundamental problem in biology.
