No Discourse whatsoever, can End in absolute Knowledge of Fact.
There may be things that are completely unknowable to us, so we must be careful not to treat the limits of our knowledge as sure guides to the limit of what there is.
It is therefore worthwhile, to search out the bounds between opinion and knowledge; and examine by what measures, in things, whereof we have no certain knowledge, we ought to regulate our assent, and moderate our persuasions.
I do not need to know all things. I remind myself that it is sufficient that I know what I know and know that without believing that I will always know what I know or that what I know will always be true.
The beliefs which we have most warrant for have no safeguard to rest on but a standing invitation to the whole world to prove them unfounded. If the challenge is not accepted, or is accepted and the attempt fails, we are far enough from certainty still; but we have done the best that the existing state of human reason admits of; we have neglected nothing that could give the truth a chance of reaching us.
It is important to realize that our inability to answer a question says nothing about whether the question itself has an answer.
There is no more common error than to assume that, because prolonged and accurate mathematical calculations have been made, the application of the result to some fact of nature is absolutely certain.
That though we are certain of many things, yet that Certainty is no absolute Infallibility, there still remains the possibility of our being mistaken in all matters of humane Belief and Inquiry.