The cartoon me writes the books cartoon people read in the cartoon world, because they need things to read there too.
It's absolutely fine when Wile E. Coyote walks in with a band-aid on his head, after a 3,000-pound rock is dropped on him. That is what Ed Wood meant by the suspension of disbelief.
It's amazing how these little guys can say things that a mortal human could never get away with. There's some sort of unspoken license... when outlandish things come out of an inanimate object, somehow it equals humor.
One of the mistakes I made was thinking chickens and penguins could sing, just like all the other animals in the 'Muppets.' But it turns out those animals are not allowed to sing words.
I say, if you believe what you read in the comic strips, then you believe that mice run around with little gold buttons on their red pants and drive cars.
The Smurfs - and they're this way in Peyo's comics as well - do have a rubbery indestructibility about them. They can get bruised & battered. But they then just sort of bounce back very quickly, like those classic cartoon characters Wiley Coyote and Tom & Jerry.
Usually cartoon characters stay a certain age; that's part of their appeal. Usually they don't grow up.
When you can't draw chameleons and you can't draw blenders, it's a bad idea to write strips where chameleons become blenders.