Leroy Hood

(Leroy "Lee" Edward Hood)

Leroy Hood
Leroy Hood
  • Born: October 10, 1938
  • Nationality: American
  • Profession: Scientist









Leroy "Lee" Edward Hood is an American biologist who has served on the faculties at the California Institute of Technology (Caltech) and the University of Washington. Hood has developed ground-breaking scientific instruments which made possible major advances in the biological sciences and the medical sciences. These include the first gas phase protein sequencer (1982), for determining the amino acids that make up a given protein; a DNA synthesizer (1983), to synthesize short sections of DNA; a peptide synthesizer (1984), to combine amino acids into longer peptides and short proteins; the first automated DNA sequencer (1986), to identify the order of nucleotides in DNA; ink-jet oligonucleotide technology for synthesizing DNA and nanostring technology for analyzing single molecules of DNA and RNA.

Quotes About
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All of the details that most of us memorize in medical school - you don't have to learn those things. They're going to be in your computer. Health, Healthcare & Medicine
Almost never does a single company have excellence in a multiplicity of disciplines.
An important finding is that by determining the genome sequences of an entire family, one can identify many DNA sequencing errors and thus greatly increase the accuracy of the data. This will ultimately help us understand the role of genetic variations in the diagnosis, treatment, and prevention of disease. Families, Children & Parenting
Anybody that thought the genome was going to directly provide drugs was a fool. Biological networks are not simple, and making drugs to affect them won't be simple.
Breast cancer isn't one disease - it's probably four or five different types, and without knowing what type a person has, you can't optimize treatment for them.
Changing the world is not easy, but its pursuit will change you profoundly.
Cloning interferon was not something I wanted to get into.
Data-intensive graph problems abound in the Life Science drug discovery and development process. Life ;Science, Mathematics, Engineering & Technology
Don't listen to the prevailing majority points of view. If you have new ideas, push them.
Don't underestimate the power of your vision to change the world. Whether that world is your office, your community, an industry or a global movement, you need to have a core belief that what you contribute can fundamentally change the paradigm or way of thinking about problems. Power
Each form of Alzheimer's disease should perturb different brain networks and so influence the concentration of different proteins that can be measured in the blood.
For some people, it's best for their mental health to know they have the gene for Huntington's and some time in the future they'll have a problem. But to other people, it would be a disaster. Time ;Health, Healthcare & Medicine
Genes are natural resources.
I already get 10 job offers a year, which is more than I can handle anyway.
I didn't want my genome to be sequenced by any of the companies that were out there doing the partial sequences just from the point of view of commercialisation.
I have good genes, and I also do lots of exercises.
I think the real problem is it's easy to persuade young kids of particular kinds of ideas, because they are flexible.
If a startup stays in Microsoft, it does not have a chance, because all it tries to do goes against what Microsoft is about.
If you go to the FDA with a drug that's only meant to treat 50 people, and it's a 95 percent cure rate, you'll get your drug approved.
If you just focus on the smallest details, you never get the big picture right.
If you know the mother's genome and the father's genome, and you see that the children have some genes that neither parent has, then you know that difference is either a mutation or a processing error.
If you look at healthcare today, it's all about disease. It's not about understanding wellness at all.
In the end, what counts is what you do.
In the late 1970s, when I was a professor at Caltech, I pioneered four instruments for analyzing genes and proteins that revolutionized modern biology - and one of these, the automated DNA sequencer, enabled the Human Genome Project.
Life is a process of evolution. Life
Many nonprofits rely on grants alone.
Medicine will be personalized and preventive: Your genome might predict that you have an 80 percent chance of breast cancer by the time you are 50, but if you take a preventive drug starting when you are 40, the chance will drop to 2 percent. Time
Most of the people who claim to be doing systems biology are really studying simple and complex molecular machines and how they function, and that is an aspect of systems biology; but it isn't. It's the networks that really capture and store and transmit and integrate and modulate and finally end up executing the biological information as it is.
My fundamental philosophy is that you owe it to society to transfer to them any knowledge you have that might be useful. Education, Learning, Knowledge & Training ;Society
My own view about knowledge is we're always better to have knowledge. Education, Learning, Knowledge & Training
The Human Genome Project has given us a genetic parts list.
The major thing is to view biology as an information science. Science, Mathematics, Engineering & Technology
The systems approach to biology will be the dominant theme in medicine.
The wellness and prevention market will outgrow the health care market. Health, Healthcare & Medicine
To manipulate the immune system, you need to find the key bottlenecks that govern the system. The T-cell is an absolute bottleneck.
We are evolutionary descendents of this marvellous panoply of life. And what that says unequivocally is we have an utter total obligation to make sure we have an environment that not only is good for us but is good for all living organisms. Life
We don't argue if drug companies create drugs that can cure humans and charge lots of money for them, even though we all have these diseases. It will be pretty hard to make a different argument for genes. Money, Coins & Minting
What is unique about humans is their individuality.
What you need to learn how to do is analyze situations and do differential diagnoses and understand the principle and the concepts rather than learn all the details, and medical school doesn't begin to do that. Health, Healthcare & Medicine
Your genome sequence will become a vital part of your medical record, thereby providing critical information about how to optimize your wellness. Health, Healthcare & Medicine